The practice of “stacking” or combining cognitive enhancement drugs and supplements to increase effectiveness is very popular, and there are many possible combinations suggested in chat rooms and forums on the Internet. Not all of them are a good idea.
Caffeine has been used for centuries as a drug which helps alleviate sleepiness. Often taken as a cup of coffee or tea, it can also be ingested in capsule form. Caffeine and Modafinil can be an effective combination. Some evidence exists, in fact, that Modafinil helps clear caffeine more quickly from the body, since it stimulates the production of the liver enzyme CYP3A4, which metabolizes caffeine, along with other drugs.
Many people suggest taking caffeine to augment the effects of Modafinil, but it needs to be used with caution. It is important to carefully monitor your intake of caffeine when using Modafinil. Too much caffeine in combination with Modafinil could lead to nervousness, insomnia, headaches, and dizziness. You should not exceed 100 mg from all sources in a day.
Piperine or Bioprene is derived from the pepper vine plant, and can greatly increase the bioavailability of certain nutrients and drugs. This may include Modafinil. Some users have found success with combining 25 mg with a 200 mg dose of Modafinil. It would be best to start at a much lower rate of 5 or 10 mg and work your way up until you find a level that works for you.
L-Theanine is derived from green tea, and can be used to temper the effects of Modafinil. It can ease the occasional feelings of anxiety or jitteriness that some people experience with Modafinil, and some swear by its ability to increase creative thought in conjunction with the focus obtained from Modafinil. 200 mg with the Modafinil, or taken later as needed, seems to be effective.
The B-complex vitamins, especially B2, B6, and B12, can help maintain energy levels and promote mental acuity. They also contribute to dopamine production which augments the effect of the Modafinil. Besides, it’s always a good idea to take your vitamins!
L-tyrosine is a non-essential amino acid which can have significant benefits when taken with Modafinil. It helps to regulate epinephrine and norepinephrine levels, which can lower stress levels, which can sometimes be elevated by Modafinil.
Oxiracetam from the racetam group of nootropics, is often used as a study aid, as it boosts intelligence levels, memory, and energy levels. When combined with Modafinil, the two provide strong benefits. Another racetam that is often used is Aniracetam. It is important to include a choline supplement to keep up acetylcholine levels, as the racetams deplete this in the body, leading to severe headaches.
There are many more combinations or stacks that are being experimented with to make the most out of the effects of Modafinil. It is important to approach any of these combinations with caution; start slow with low dosages until you know what impact the combinations will have on you.
Binding agents also influence the efficacy of a drug. While they are non-medicinal ingredients, they are important to help deliver the drug effectively. While Cephalon uses lactose in its Provigil, most Indian manufacturers use cellulose, which fewer people are allergic to.